Here, we examine the impact of calcium ions on CoV entry. This knowledge can be leveraged to stop the spread of infection. Thermodynamic, kinetic, and intermolecular interactions are useful to understand molecular level FP interactions with the host membrane. It is the physico-chemical interactions of the FP with the host membrane that anchors it, enabling the necessary deformations of the membrane leading to delivery of the viral genome into the cell when a fusion pore opens. Within S, the region that directly interacts with the membrane is called the fusion peptide, FP. For coronavirus, entry into a host cell is mediated by a single glycoprotein protruding from its membrane envelope, called spike (S). Focusing on the CoV replication cycle, specifically the entry steps involving membrane fusion, is an astute choice because of the conservation of the fusion machinery and mechanism across the CoV family. The coronavirus disease 2019 (COVID-19) necessitates develop of effective therapies against the causative agent, SARS -CoV-2, and other pathogenic coronaviruses (CoV) that have yet to emerge. Professor Susan Daniel, Cornell University: Regulation of the coronavirus fusion peptide interaction with the host membrane and its impact on viral infectivity Upcoming talks Our next will be announced soon, so please check back for details!
You can find our upcoming seminars on our talks.cam listings, and see our previous speakers below. We endeavour to open the events to as wide an audience as possible, and will share recordings where we are able, but due to the nature of research talks, they often feature pre-publication results, so this is not always possible. The seminars are predominantly for an internal audience, but are often open to all members of the University of Cambridge, and sometimes wider. We hope they will inspire new ideas for us all to take into our own research. This is a fantastic opportunity for us to hear from other leading researchers, develop new connections and collaborations, and discuss some of the wider questions in our field. Our departmental seminar series, Bigger Picture Talks, runs throughout the academic year, inviting thought-leaders from across the world driving significant advances in our impact areas of energy, health and sustainability to share and discuss their work with us.
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